Scientists from the Murcian Institute of Biosanitary Research (IMIB) -Arrixaca have described for the first time the mechanism by which some plant extracts are capable of promoting and improving wound healing.
Researchers have described how "oleanolic acid (a compound obtained from the olive leaf) is capable of activating important molecular pathways for the migration of cells from the edge of a wound and accelerating its closure", explains David Armero, one of the members of the team and currently the dean of the Faculty of Nursing of the University of Murcia (UMU).
The work will optimize the closure of skin wounds, such as diabetic foot or pressure ulcers, which affect 1% of the population.
The results obtained, published in the journalPlos One, are key to developing new drugs and strategies to optimize the closure of skin wounds in general and chronic wounds in particular, such as diabetic foot or pressure ulcers.
These injuries represent a prominent public health problem as they affect 1% of the population, representing up to 3% of the total health expenditure for treatment and complications.
The team, coordinated by Francisco J. Nicolás, is made up of UMU professors María Ruzafa, Antonio Jesús Ramos and David Armero, and researchers Ángel Bernabé and Sergio Liarte from IMIB-Hospital Clínico Universitario Virgen de la Arrixaca.
Bernabé-García Á, Armero-Barranco D, Liarte S, Ruzafa-Martínez M, Ramos-Morcillo AJ, Nicolás FJ (2017) Oleanolic acid induces migration in Mv1Lu and MDA-MB- 231 epithelial cells involving EGF receptor and MAP kinases activation. PLoS ONE 12 (2): e0172574. doi: 10.1371 / journal.pone.0172574